Protein Details: Glutamate receptor 2.1

Protein ID

ICDB_Pro_0173

Protein Name

Glutamate receptor 2.1

Gene Name

GLR2.1; GLR3; At5g27100; A_TM021B04.3; T21B4.10

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

901 amino acids

AlphaFoldDB

AF-O04660-F1-model_v4.pdb

Function

Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.

Sequence

MKRENNLVLSLLFFVIVFLMQVGEAQNRITNVNVGIVNDIGTAYSNMTLLCINMSLSDFYSSHPETQTRLVTTVVDSKNDVVTAAAAALDLITNKEVKAILGPWTSMQAQFMIEMGQKSQVPIVTYSATSPSLASIRSQYFFRATYDDSSQVHAIKEIIKLFGWREVAPVYVDDTFGEGIMPRLTDVLQEINVRIPYRTVISPNATDDEISVELLRMMTLPTRVFVVHLVELLASRFFAKATEIGLMKQGYVWILTNTITDVLSIMNETEIETMQGVLGVKTYVPRSKELENFRSRWTKRFPISDLNVYGLWAYDATTALALAIEEAGTSNLTFVKMDAKRNVSELQGLGVSQYGPKLLQTLSRVRFQGLAGDFQFINGELQPSVFEIVNVNGQGGRTIGFWMKEYGLFKNVDQKPASKTTFSSWQDRLRPIIWPGDTTSVPKGWEIPTNGKRLQIGVPVNNTFQQFVKATRDPITNSTIFSGFSIDYFEAVIQAIPYDISYDFIPFQDGGYDALVYQVYLGKYDAVVADTTISSNRSMYVDFSLPYTPSGVGLVVPVKDSVRRSSTIFLMPLTLALWLISLLSFFIIGLVVWVLEHRVNPDFDGPGQYQLSTIFWFSFSIMVFAPRERVLSFWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLHPTVTNINSLLAKGESVGYQSSFILGRLRDSGFSEASLVSYGSPEHCDALLSKGQAEGGVSAVLMEVPYVRIFLGQYCNKYKMVQTPFKVDGLGFVFPIGSPLVADISRAILKVEESNKANQLENAWFKPIDESCPDPLTNPDPNPSVSFRQLGFDSFWVLFLVAAIVCTMALLKFVYQFLKENPNQRNLRVLWEKFNEPDQKSYIKDVTKCQCSSGQGMPKNGQEGANAVNNGN

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed predominantly in roots. First strongly detected in all cell types of the root except at the apex. Later expressed at the root-shoot junction. Later expressed at the root-shoot junction. Later expressed at the root-shoot junction.

DOI ID

10.1038/35048507; 10.1111/tpj.13415; 10.1126/science.292.5521.1486b; 10.1093/oxfordjournals.molbev.a004165

RefSeq

NP_198062.2